Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats
نویسندگان
چکیده
منابع مشابه
Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats
Background/Aims Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery...
متن کاملEffect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.
BACKGROUND/AIM The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT(3)) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT(4) receptor agonist. METHODS Di...
متن کاملEVect of diVerent prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats
Background/Aim—The eVects of diVerent prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These eVects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT3) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT4 receptor agonist. Methods—DiVerent de...
متن کاملGastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber.
To develop a therapeutic for functional dyspepsia (FD), a prokinetic agent, DA-9701 has been newly formulated with Pharbitis Semen and Corydalis Tuber and we evaluated the gastroprokinetic effects of DA-9701 in comparison with conventional prokinetics. Oral administration with DA-9701 not only significantly accelerated gastric emptying in normal rats but also restored the delayed gastric emptyi...
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ژورنال
عنوان ژورنال: Journal of Neurogastroenterology and Motility
سال: 2017
ISSN: 2093-0879,2093-0887
DOI: 10.5056/jnm16003